Hartmut Jaeschke : rechercher sur Z-Library

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Articles (282)
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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

Jaeschke, Hartmut, McGill, Mitchell R., Ramachandran, Anup

Journal:

Drug Metabolism Reviews

Année:

2012

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2012

Letter to the Editor Regarding the Article “The Chrysin effect in prevention of acetaminophen-induced hepatotoxicity in rat” by Mohammadi and Coworkers (2019)

Jaeschke, Hartmut, Ramachandran, Anup

Journal:

Chemical Research in Toxicology

Année:

2020

Langue:

english

Fichier:

PDF, 790 KB

english, 2020

Lipid peroxidation as molecular mechanism of liver cell injury during reperfusion after ischemia

W.Rodney Mathews, David M. Guido, Michael A. Fisher, Hartmut Jaeschke

Journal:

Free Radical Biology and Medicine

Année:

1994

Langue:

english

Fichier:

PDF, 737 KB

english, 1994

The role of acrolein in allyl alcohol-induced lipid peroxidation and liver cell damage in mice

Hartmut Jaeschke, Christin Kleinwaechter, Albrecht Wendel

Journal:

Biochemical Pharmacology

Année:

1987

Langue:

english

Fichier:

PDF, 957 KB

english, 1987

Reactive oxygen species in the normal and acutely injured liver

Hartmut Jaeschke, Anup Ramachandran

Journal:

Journal of Hepatology

Année:

2011

Langue:

english

Fichier:

PDF, 698 KB

english, 2011

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

McGill, Mitchell R., Jaeschke, Hartmut

Journal:

Pharmaceutical Research

Année:

2013

Langue:

english

Fichier:

PDF, 490 KB

english, 2013

Comments on caspase-mediated anti-apoptotic effect of Ginsenoside Rg5, a main rare ginsenoside, on acetaminophen-induced hepatotoxicity in mice

Jaeschke, Hartmut

Journal:

Journal of Agricultural and Food Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 168 KB

english, 2018

Animal models of drug-induced liver injury

McGill, Mitchell R., Jaeschke, Hartmut

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Année:

2018

Langue:

english

Fichier:

PDF, 3.37 MB

english, 2018

Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity

Du, Kuo, Ramachandran, Anup, Weemhoff, James L., Woolbright, Benjamin L., Jaeschke, Andrew H., Chao, Xiaojuan, Ding, Wen-Xing, Jaeschke, Hartmut

Journal:

Archives of Toxicology

Année:

2018

Langue:

english

Fichier:

PDF, 16.17 MB

english, 2018

The role of oxidant stress in acetaminophen-induced liver injury

Jaeschke, Hartmut, Ramachandran, Anup

Journal:

Current Opinion in Toxicology

Année:

2020

Fichier:

PDF, 1.06 MB

2020

Novel strategies for the treatment of acetaminophen hepatotoxicity

Akakpo, Jephte Y., Ramachandran, Anup, Jaeschke, Hartmut

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Année:

2020

Fichier:

PDF, 1.17 MB

2020

4-methylpyrazole protects against acetaminophen-induced acute kidney injury

Akakpo, Jephte Y., Ramachandran, Anup, Orhan, Hilmi, Curry, Steven C., Rumack, Barry H., Jaeschke, Hartmut

Journal:

Toxicology and Applied Pharmacology

Année:

2020

Fichier:

PDF, 6.29 MB

2020

Mass spectrometric quantification of cysteine-containing leukotrienes in rat bile using 13C-labeled internal standards

Mark J. Raftery, Ulla Justesen, Hartmut Jaeschke, Simon J. Gaskell

Journal:

Biological Mass Spectrometry = Journal of Mass Spectrometry (Wiley)

Année:

1992

Langue:

english

Fichier:

PDF, 741 KB

english, 1992

Chemie in Wolken, Nebel und Niederschlag

Hartmut Herrmann, Wolfgang Jaeschke, Detlev Möller

Journal:

Chemie in unserer Zeit

Année:

2007

Langue:

german

Fichier:

PDF, 1.04 MB

german, 2007

Monoclonal antibody against the CD18 adhesion molecule stimulates glucose uptake by the liver and hepatic nonparenchymal cells

Abraham P. Bautista, Zoltan Spolarics, Hartmut Jaeschke, C. Wayne Smith, John J. Spitzer

Journal:

Hepatology

Année:

1993

Langue:

english

Fichier:

PDF, 856 KB

english, 1993

Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver

Dr. Hartmut Jaeschke, Anwar Farhood, Abraham P. Bautista, Zoltan Spolarics, John J. Spitzer, C. Wayne Smith

Journal:

Hepatology

Année:

1993

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1993

Contribution of complement-stimulated hepatic macrophages and neutrophils to endotoxin-induced liver injury in rats

Dr. Hartmut Jaeschke, Anwar Farhood, C. Wayne Smith

Journal:

Hepatology

Année:

1994

Langue:

english

Fichier:

PDF, 801 KB

english, 1994

Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure

Naeem A. Essani, Michael A. Fisher, Anwar Farhood, Anthony M. Manning, C. Wayne Smith, Hartmut Jaeschke

Journal:

Hepatology

Année:

1995

Langue:

english

Fichier:

PDF, 972 KB

english, 1995

Are cultured liver cells the right tool to investigate mechanisms of liver disease or hepatotoxicity?

Hartmut Jaeschke

Journal:

Hepatology

Année:

2003

Langue:

english

Fichier:

PDF, 341 KB

english, 2003

Reduced oncotic necrosis in fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation

Jaspreet S. Gujral, Jie Liu, Anwar Farhood, Hartmut Jaeschke

Journal:

Hepatology

Année:

2004

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2004

Inflammation and drug hepatotoxicity: Aggravation of injury or clean-up mission?

Hartmut Jaeschke, Cathleen Cover, Mary Lynn Bajt

Journal:

Hepatology

Année:

2005

Langue:

english

Fichier:

PDF, 323 KB

english, 2005

How relevant are neutrophils for acetaminophen hepatotoxicity?

Hartmut Jaeschke

Journal:

Hepatology

Année:

2006

Langue:

english

Fichier:

PDF, 239 KB

english, 2006

Neutrophil depletion protects against murine acetaminophen hepatotoxicity: Another perspective

Hartmut Jaeschke, Jie Liu

Journal:

Hepatology

Année:

2007

Langue:

english

Fichier:

PDF, 83 KB

english, 2007

Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury

Akira Uchiyama, Jae-Sung Kim, Kazuyoshi Kon, Hartmut Jaeschke, Kenichi Ikejima, Sumio Watanabe, John J. Lemasters

Journal:

Hepatology

Année:

2008

Langue:

english

Fichier:

PDF, 587 KB

english, 2008

Innate immunity and acetaminophen-induced liver injury: Why so many controversies?

Hartmut Jaeschke

Journal:

Hepatology

Année:

2008

Langue:

english

Fichier:

PDF, 59 KB

english, 2008

The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers

Sven Schüngel, Laura Elisa Buitrago-Molina, Padmavathi devi Nalapareddy, Margitta Lebofsky, Michael P. Manns, Hartmut Jaeschke, Atan Gross, Arndt Vogel

Journal:

Hepatology

Année:

2009

Langue:

english

Fichier:

PDF, 5.48 MB

english, 2009

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

Chieko Saito, Claudia Zwingmann, Hartmut Jaeschke

Journal:

Hepatology

Année:

2010

Langue:

english

Fichier:

PDF, 2.43 MB

english, 2010

No evidence for caspase-dependent apoptosis in acetaminophen hepatotoxicity

Hartmut Jaeschke, C. David Williams, Anwar Farhood

Journal:

Hepatology

Année:

2011

Langue:

english

Fichier:

PDF, 387 KB

english, 2011

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

Mitchell R. McGill, Hui-Min Yan, Anup Ramachandran, Gordon J. Murray, Douglas E. Rollins, Hartmut Jaeschke

Journal:

Hepatology

Année:

2011

Langue:

english

Fichier:

PDF, 4.03 MB

english, 2011

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

Hong-Min Ni, Abigail Bockus, Nikki Boggess, Hartmut Jaeschke, Wen-Xing Ding

Journal:

Hepatology

Année:

2012

Langue:

english

Fichier:

PDF, 2.36 MB

english, 2012

Chemokines and liver inflammation: The battle between pro- and anti-inflammatory mediators

Hartmut Jaeschke

Journal:

Hepatology

Année:

1997

Langue:

english

Fichier:

PDF, 167 KB

english, 1997

Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and fas-antibody–induced liver injury

Judy A. Lawson, Michael A. Fisher, Carol A. Simmons, Anwar Farhood, Dr. Hartmut Jaeschke

Journal:

Hepatology

Année:

1998

Langue:

english

Fichier:

PDF, 688 KB

english, 1998

Glutathione peroxidase–deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress

Hartmut Jaeschke, Ye-Shih Ho, Michael A. Fisher, Judy A. Lawson, Anwar Farhood

Journal:

Hepatology

Année:

1999

Langue:

english

Fichier:

PDF, 311 KB

english, 1999

Kupffer cell–induced oxidant stress during hepatic ischemia-reperfusion: Does the controversy continue?

Hartmut Jaeschke

Journal:

Hepatology

Année:

1999

Langue:

english

Fichier:

PDF, 41 KB

english, 1999

Antioxidant gene therapy and hepatic ischemia-reperfusion injury

Hartmut Jaeschke

Journal:

Hepatology

Année:

2002

Langue:

english

Fichier:

PDF, 64 KB

english, 2002

Anti-selectin therapy against hepatic ischemia-reperfusion injury

Hartmut Jaeschke

Journal:

Hepatology

Année:

2003

Langue:

english

Fichier:

PDF, 50 KB

english, 2003

Regulation of apoptotic signaling pathways in hepatocytes in vivo

Hartmut Jaeschke, Mary Lynn Bajt

Journal:

Hepatology

Année:

2003

Langue:

english

Fichier:

PDF, 106 KB

english, 2003

Manipulation of mouse organ glutathione contents II: Time and dose-dependent induction of the glutathione conjugation system by phenolic antioxidants

Hartmut Jaeschke, Albrecht Wendel

Journal:

Toxicology

Année:

1986

Langue:

english

Fichier:

PDF, 662 KB

english, 1986

Multiple scan modes in the hybrid tandem mass spectrometric screening and characterization of the glutathione conjugate of 2-furamide

Kevin D. Ballard, Mark J. Raftery, Hartmut Jaeschke, Simon J. Gaskell

Journal:

Journal of the American Society for Mass Spectrometry

Année:

1991

Langue:

english

Fichier:

PDF, 1.04 MB

english, 1991

Neutrophil-mediated tissue injury in alcoholic hepatitis

Hartmut Jaeschke

Journal:

Alcohol

Année:

2002

Langue:

english

Fichier:

PDF, 75 KB

english, 2002

Ischemia-reperfusion activates the nuclear transcription factor NF-κB and upregulates messenger RNA synthesis of adhesion molecules in the liver in vivo

Frank P. Bell, Naeem A. Essani, Anthony M. Manning, Hartmut Jaeschke

Journal:

Hepatology Research

Année:

1997

Langue:

english

Fichier:

PDF, 933 KB

english, 1997

Reactive oxygen and mechanisms of inflammatory liver injury

Hartmut Jaeschke

Journal:

Journal of Gastroenterology and Hepatology

Année:

2000

Langue:

english

Fichier:

PDF, 94 KB

english, 2000

Heme oxygenase-1 induction in hepatocytes and non-parenchymal cells protects against liver injury during endotoxemia

Robert B Dorman, Mary Lynn Bajt, Anwar Farhood, January Mayes, Hartmut Jaeschke

Journal:

Comparative Hepatology

Année:

2004

Langue:

english

Fichier:

PDF, 460 KB

english, 2004

Peroxynitrite formation and sinusoidal endothelial cell injury during acetaminophen-induced hepatotoxicity in mice

Tamara R Knight, Hartmut Jaeschke

Journal:

Comparative Hepatology

Année:

2004

Langue:

english

Fichier:

PDF, 3.21 MB

english, 2004

Chlorotyrosine protein adducts are reliable biomarkers of neutrophil-induced cytotoxicityin vivo

Jaspreet S Gujral, Jack A Hinson, Hartmut Jaeschke

Journal:

Comparative Hepatology

Année:

2004

Langue:

english

Fichier:

PDF, 1.02 MB

english, 2004

Drug-induced intrahepatic cholestasis: characterization of different pathomechanisms

Herbert Krell, Jürgen Metz, Hartmut Jaeschke, Hartmut Höke, Erich Pfaff

Journal:

Archives of Toxicology

Année:

1987

Langue:

english

Fichier:

PDF, 1.60 MB

english, 1987

Mechanisms of reperfusion injury after warm ischemia of the liver

Hartmut Jaeschke

Journal:

Journal of Hepato-Biliary-Pancreatic Sciences

Année:

1998

Langue:

english

Fichier:

PDF, 95 KB

english, 1998

Manipulation of mouse organ glutathione contents I: Enhancement by oral administration of butylated hydroxyanisole and butylated hydroxytoluene

Hartmut Jaeschke, Albrecht Wendel

Journal:

Toxicology

Année:

1985

Langue:

english

Fichier:

PDF, 515 KB

english, 1985

Choleresis and increased biliary efflux of glutathione induced by phenolic antioxidants in rats

Hartmut Jaeschke, Albrecht Wendel

Journal:

Toxicology

Année:

1988

Langue:

english

Fichier:

PDF, 618 KB

english, 1988

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

Hartmut Jaeschke

Journal:

Journal of Gastroenterology and Hepatology

Année:

2011

Langue:

english

Fichier:

PDF, 304 KB

english, 2011